Omega-3 Index
O3I - Omega-3 Index. Measures EPA and DHA omega-3 fatty acids in red blood cell membranes as a percentage of total fatty acids. A validated marker of cardiovascular risk and brain health. Reflects dietary intake over the previous 2-3 months.
What It Measures
The Omega-3 Index measures the amount of two key omega-3 fatty acids, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), present in the membranes of your red blood cells, expressed as a percentage of total fatty acids. Because red blood cells have a lifespan of roughly 120 days, this test reflects your average omega-3 intake over the previous two to three months rather than what you ate yesterday, giving a much more stable and meaningful picture than a one-off dietary snapshot. Omega-3 fatty acids matter because they are essential building blocks that your body cannot manufacture on its own, you must obtain them from food or supplements. They play a central role in keeping your heart, brain, and joints healthy.
EPA and DHA are incorporated directly into the membranes of your cells, where they help to keep those membranes flexible, support healthy inflammatory responses, and contribute to the electrical signalling in your heart and nervous system. A helpful analogy is to think of your cell membranes like the walls of a house: omega-3 fatty acids are the quality building materials that keep those walls supple and well insulated rather than rigid and brittle. An Omega-3 Index above 8 per cent is generally considered desirable, while levels below 4 per cent are associated with less favourable outcomes. Most people in the UK fall somewhere between 4 and 6 per cent.
Your levels are primarily influenced by how much oily fish you eat, salmon, mackerel, sardines, and anchovies are particularly rich sources, as well as whether you take fish oil or algae-based omega-3 supplements. Genetics, age, and body weight can also play a modest role. If your Omega-3 Index is lower than you would like, dietary adjustments or supplementation can often bring about meaningful improvements within a few months. Your GP or a registered dietitian can help you decide on the best approach for your individual needs.
What Your Results Mean
See where your Omega-3 Index sits
A blood test that includes Omega-3 Index, analysed with AI and read against your wider results.

